Lectura recomendada por el Prof. Dr. Pedro Kasdorf

Conferencia 2015: “Radioterapia en el cáncer de piel”

  • Fuente: Review Cancer. 2018 Apr 1;124(7):1335-1341. doi: 10.1002/cncr.31221. Epub 2018 Jan 16.
  • Autores: Melissa Pilewskie, Monica Morrow.

Resumen: The appropriate negative margin width for women undergoing breast-conserving surgery for both ductal carcinoma in situ (DCIS) and invasive carcinoma is controversial. This review examines the available data on the margin status for invasive breast cancer and DCIS, and highlights the similarities and differences in tumor biology and standard treatments that affect the local recurrence (LR) risk and, therefore, the optimal surgical margin. Consensus guidelines support a negative margin, defined as no ink on tumor, for invasive carcinoma treated with breast-conserving therapy. Because of differences in the growth pattern and utilization of systemic therapy, a margin of 2 mm has been found to minimize the LR risk for women with DCIS undergoing lumpectomy and radiation therapy (RT). Wider negative margins do not improve local control for DCIS or invasive carcinoma when they are treated with lumpectomy and RT. Re-excision for negative margins should be individualized, and the routine practice of performing additional surgery to obtain a wider negative margin is not supported by the literature.

Link al artículohttps://pubmed.ncbi.nlm.nih.gov/29338088/